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Nattie's avatar

"Skeptical of the idea that it represents a real lack, cause wtf is in chilies/tomato sauce?"

There are more nutrients than just vitamins and minerals and amino acids! Many other organic acids feed into the Krebs cycle. For example, citric acid, malic acid, acetic acid, etc are all found in foods and are used to produce energy. Tomatoes and peppers both contain citric acid, malic acid, and, well ascorbic acid is vitamin C. But for example, you need vitamin C to make carnitine to be able to shuttle fatty acids to be burned, so craving vitamin C makes sense after a fast because you weren't getting carnitine from meat but your body still had to burn fat, so it was drawing on your vitamin C. And you need plenty of citric acid to make acetyl-CoA, not just for energy production but lots of other functions (reminder that another name for the Krebs cycle is the citric acid cycle). You need malic acid to keep the cycle going, but it comes a few steps before recycling citrate so you may have just used it up that way, though malic acid does other things in the body too.

It is possible to have genetic variants that make it difficult to synthesize or recycle any of those as well, such that you may struggle if you're not eating those foods instead.

You can get an organic acids test (OAT) here: https://truehealthlabs.com/product/organic-acids-urine-test/

I was incredibly low in citrate when I took one a few weeks ago. I think an organic acids test could probably tell you a lot more helpful information about dysregulated metabolic pathways in your body, and maybe a full genome could help you figure out why you seem to need such a specific diet. Sometimes there are things you can do to circumvent genetic inborn errors of metabolism, like simply supplement the thing your body struggles to produce when possible, or supplement larger doses of the cofactors for your goofy-shaped enzyme that doesn't react as easily as it should, so that the chances of it reacting is much higher. For example, I have an ACAD9 problem so that I can't metabolize very long chain fatty acids and have some issues metabolizing long chain fatty acids. That is reflected in my OmegaQuant as well. Because it's involved in assembling complex I of the respiration chain and it is not an issue of producing some other nutrient, but rather difficulty breaking down what is there, my only recourse is to make the enzyme work better. Taking riboflavin makes things pretty functional, and it is *not* an amount of riboflavin I could feasibly get from food (which is typically the case with genetic stuff). I also do better with some carnitine supplementation and glutamine to work around issues with that same gene.

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John Lawrence Aspden's avatar

The chili/tomato thing is weird, but interesting. I can imagine that you've come to associate tomatoes with protein by eating tomatoes and beef together all the time, (I think when we're in some sort of deficit we tend to crave *the taste that last fixed a similar deficit*) but I'm surprised that your appetite hasn't figured out that tomatoes/chilis alone don't do the trick yet, and focussed itself on getting more beef. Still, if it's usually true that tomatoes/chili come with protein I can see why it might stay confused.

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