I'm staring at this chart trying to figure out which column to sort by; 6:3 ratio? Linoleic? What do you think? Sorting by 6:3 ratio canola looks good, and flaxseed looks great...
I haven't asked, but their test says it's "whole blood" which includes what you ate, adipose flux, and RBCs. So I'm pretty sure that's what they'd say..
But if for some reason, they might know how it compares to an adipose tissue biopsy. Maybe the reason why nobody does it is because it’s 1:1 to a fasted blood draw or some other formula.
Might help explain a little bit why this potato diet round is going better than the last one few years ago. I've been more explicitly avoiding PUFAs in the last 4 months, and my omegaquant from feb 2024 puts me at 20% linoleic acid.
Nice! Especially in the beginning, there's a huge benefit I think. Even before you cut your adipose LA, just no longer hijacking your endocannabinoid system daily or weekly is huge. I forget, did you post your OQ in the subreddit? If not, I'd love to add it to the DB.
edit: also explains maybe why potato totally failed for me, I was probably close to my most PUFA'd ever when I tried it. And when I finally added sauce, I added mayo/ranch... sigh.
I'm wondering how blood donation (or other kinds of phlebotomy) would affect the OmegaQuant readings, that may be a fun experiment. Maybe it's a way to more quickly rid yourself of LA? For females lactation might also be interesting to look at - although I'm not sure if the milk resembles the dietary fatty acid profile or the stored fatty acid profile or a bit of both?
I don't know if it would do much to your PUFAs though, because the FFAs/triglycerides currently in 1 quart or whatever of your blood isn't the problem, it's the dozens of pounds in your adipose tissue :)
Very interesting, they have 13.9% (sourced from another study, apparently) on average. In that study, almost nobody is <10% LA and as high as 25% (30% with error bars).
Someone associated with omegaquant is one of the authors here.
THis is a serious epsitemic challenge for you I think... It looks like a good study and you can either search for a reason to dismiss it, or move to a position of more uncertainty. I think the latter is the fairer move!
Haha, it's not that big a challenge because MPT thinks of LA as a flux issue. Tucker Goodrich compares this to "burning houses were found to have no gasoline, so gasoline doesn't cause fires."
The problem is that the gasoline is already burned. You'd want to be looking for oxidation ("burn products") of gasoline and see if they correlate with inflammation and diseases (which they tend to).
It's not about "fair," it's about "does it measure the right things."
some day.....not too soon , MR spectroscopy could be used determine the fat species in macro fat (viscerals and subcutaneous). You could approximate the percentages of most species.
Great stuff, as usual. I'll throw in here that dietary lithium inhibits lipoprotein lipase.
I'm staring at this chart trying to figure out which column to sort by; 6:3 ratio? Linoleic? What do you think? Sorting by 6:3 ratio canola looks good, and flaxseed looks great...
https://en.wikipedia.org/wiki/Polyunsaturated_fat#Dietary_sources
I'm not a big fan of the ratio. I'm not sure if to sort "just" by LA or total PUFA, but either of those.
I asked some doctor friends about an adipose tissue biopsy and they also haven’t heard of it.
Have you asked the omegaquant people directly how their test compares to an adipose tissue biopsy?
I haven't asked, but their test says it's "whole blood" which includes what you ate, adipose flux, and RBCs. So I'm pretty sure that's what they'd say..
But if for some reason, they might know how it compares to an adipose tissue biopsy. Maybe the reason why nobody does it is because it’s 1:1 to a fasted blood draw or some other formula.
I've sent them an email, we'll see if they reply :)
They replied with this study: https://academic.oup.com/aje/article/162/4/373/105354
Might help explain a little bit why this potato diet round is going better than the last one few years ago. I've been more explicitly avoiding PUFAs in the last 4 months, and my omegaquant from feb 2024 puts me at 20% linoleic acid.
Nice! Especially in the beginning, there's a huge benefit I think. Even before you cut your adipose LA, just no longer hijacking your endocannabinoid system daily or weekly is huge. I forget, did you post your OQ in the subreddit? If not, I'd love to add it to the DB.
edit: also explains maybe why potato totally failed for me, I was probably close to my most PUFA'd ever when I tried it. And when I finally added sauce, I added mayo/ranch... sigh.
Not sure but here you go https://www.reddit.com/r/SaturatedFat/comments/1f0l1nf/my_feb_2024_omegaquant_result/
I'm wondering how blood donation (or other kinds of phlebotomy) would affect the OmegaQuant readings, that may be a fun experiment. Maybe it's a way to more quickly rid yourself of LA? For females lactation might also be interesting to look at - although I'm not sure if the milk resembles the dietary fatty acid profile or the stored fatty acid profile or a bit of both?
I recently did my 2nd blood donation. It's fun!
I don't know if it would do much to your PUFAs though, because the FFAs/triglycerides currently in 1 quart or whatever of your blood isn't the problem, it's the dozens of pounds in your adipose tissue :)
My guess is that better algorithms and hardware have been developed since 2020.
OK here is a focus on adipose fatty acids using MR spectroscopy
https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.28471
You can access the fatty acid profile in the stored form...ie triglycerides.
Very interesting, they have 13.9% (sourced from another study, apparently) on average. In that study, almost nobody is <10% LA and as high as 25% (30% with error bars).
Found a study that may cause you to update some priors!
https://www.sciencedirect.com/science/article/abs/pii/S0002916524007123?via%3Dihub
Someone associated with omegaquant is one of the authors here.
THis is a serious epsitemic challenge for you I think... It looks like a good study and you can either search for a reason to dismiss it, or move to a position of more uncertainty. I think the latter is the fairer move!
Haha, it's not that big a challenge because MPT thinks of LA as a flux issue. Tucker Goodrich compares this to "burning houses were found to have no gasoline, so gasoline doesn't cause fires."
The problem is that the gasoline is already burned. You'd want to be looking for oxidation ("burn products") of gasoline and see if they correlate with inflammation and diseases (which they tend to).
It's not about "fair," it's about "does it measure the right things."
Yes
some day.....not too soon , MR spectroscopy could be used determine the fat species in macro fat (viscerals and subcutaneous). You could approximate the percentages of most species.
Oh so you'd be able to tell your fatty acid profile from an MRI? That'd be amazing.
https://www.ismrm.org/19/program_files/Tu02.htm
https://www.sciencedirect.com/science/article/abs/pii/B9780128170571000299
etc etc etc....
How much do you think skin LA content would differ from adipose content?
Not sure, honestly. Maybe closer to Red blood cell phospholipids?