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You're right I've seen studies when mice binge-eat and become fat, but to my knowledge it's on high-PUFA chow, like in this study: doi.org/10.1371/journal… (21% total fat, of which 21% PUFA as opposed to 3% total fat for control). The control mice did not overeat. They even day that "it seems that the acute activation of the mesolimbic p…
You're right I've seen studies when mice binge-eat and become fat, but to my knowledge it's on high-PUFA chow, like in this study: https://doi.org/10.1371/journal.pone.0087478 (21% total fat, of which 21% PUFA as opposed to 3% total fat for control). The control mice did not overeat. They even day that "it seems that the acute activation of the mesolimbic pathway [that makes mice overeat] is mainly mediated by the HFD [read "high-PUFA diet"] itself, rather than the eaten weight or the caloric content."
Now if you have other examples I'm all ears.
My guess is that there's probably some variation as you say, but none that would lead to the situation we have know.
No, that is the point I'm making -- the mice are 'healthy' when they start eating the high-PUFA diet, aren't they? If there exists even one food that a healthy animal will overeat (and become unhealthy), there you are.
It's a question though if salsa mice would become unhealthy upon "overeating" salsa-laced (otherwise healthy, i.e. non-PUFA) food. Or would they just gain a bit of fat, not be hungry for a while, and balance out?
In presence of a common "metabolic poison" though, even short-term hyperphagic agents like sour and spicy and sweet flavor (aka good tasting food lol) would become "obesogenic" agents.