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1. I regained all my weight in about 2 years. Maybe a little less. So pretty much the exact same time frame I lost it. Why did it stop working? Why did it start working again with the cream? This seems pretty important to me.

2. That's why I don't think "disordered" or "relationship to food" is useful. Most people (93% in the US) are metabolically unhealthy. It is not surprising that you'd have to do something pretty extreme to unobese yourself. If the order is unhealthy, only the disordered will be healthy.

I also wonder why some people stay lean. Whatever in the environment has made more and more people overweight and obese, not everyone is affected. Although it is almost everyone at this point. The number of people unaffected shrinks every year. I think we tripled (!) the number of diabetics since 2000. Soon, even people like your partner might no longer be immune. But we should figure out what makes him immune, cause it might help us understand the root cause.

He is naturally satiated whereas we are not. Why?!

To me, GLP-1 is an excuse. It's saying "I don't want to know." 99% of people were lean 100 years ago. Now it's <25%. Why?! Again, this seems really important to understand.

3. Yes, but those studies restricted calories. My REE is not suppressed after losing 75lbs. Clearly, you shouldn't be losing weight by restricting calories. It's a terrible idea! That's one of the reasons I think GLP-1 drugs are so dangerous. Instead of fixing the root cause, they just use a sledgehammer and probably do a lot of damage in the long run.

7. There must be individual differences, maybe genetic or something else. We know there are HUGE differences when it comes to dairy, glucose, fat, and protein metabolism. It would not be a huge surprise if some people reacted better to some diets than others.

It's pretty normal to see what you describe: less protein (w/ carbs held equal) -> higher ketones.

If there are "beginner results" on keto, why? What causes keto to work and then stop working?

8. Yes, some people. But most are not. Like your partner.

9. Congrats, 30lbs is amazing! That spontaneous appetite & reduction in food intake is what we're looking for. Overweight people have so much energy in their adipose tissue, they should be satiated all day long! That's thousands of carolies dumped into your bloodstream all day long. How come overweight people are able to eat at all?!

Diets that fix fuel partitioning lead to this spontaneous satiety and potentially eating less. That's good, cause it means you unlocked access to your body fat.

If you simply eat less, but you don't unlock your body fat, guess what's being burned instead... lean tissue. That's why I highly recommend against restricting calories.

Good luck!

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